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Neuropathic pain originates from damage to neurons within the peripheral or central nervous system. This damage leads to an exaggeration of pain signals sent to the brain, resulting in a persistent and often severe pain experience.

Neuropathic Pain

Diabetic Peripheral Neuropathy (DPN) is a common complication of diabetes, where up to 50% of those who have diabetes are affected by it. DPN makes patients vulnerable to experience limitations in their functioning by having symptoms of remitting pain and unsteadiness. Some of the overall complications that patients end up having include foot ulceration and amputation due to health care costs, loss of work and a reduced quality of life. 

Diabetic Peripheral Neuropathy (DPN) and Depression

Based on the description of the individual's experience, what is the most likely underlying cause of their persistent sensation? Explain your reasoning by connecting the symptoms to the function of the nervous system.

Interpreting Atypical Pain Signals

Diabetic Peripheral Neuropathy and Depression: Dancing with Wolves? - Mini-Review and Commentary on Alghafri et al. “Screening for depressive symptoms amongst patients with diabetic peripheral neuropathy”

An individual experiences a persistent, shooting, and burning pain in their leg, even though a past injury in that area has completely healed and there are no visible signs of tissue damage. The pain is often triggered by a light touch that would not normally be painful. Which of the following best explains the underlying cause of this type of pain?

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