- Inflammatory Markers
- Blood Cell Count
- Coagulatory Markers


Biological Markers

Ohio State University, Columbus

Smith College

MIS-C is a rare but serious condition associated with COVID-19 that has been reported in children from Europe and North America. The clinical features of MIS-C may be similar to those of Kawasaki disease, Kawasaki disease shock syndrome, and toxic shock syndrome

They include persistent fever, hypotension, gastrointestinal symptoms, rash, myocarditis, and laboratory findings associated with increased inflammation; respiratory symptoms may be lacking

Multisystem inflamatory syndrome in kids

MIS-C "is a condition where different body parts can become inflamed, including the heart, lungs, kidneys, brain, skin, eyes, or gastrointestinal organs. This rampant inflammation has been recorded in multiple organ systems; yet, clinical research into the pathogenesis of the disease is insufficient. However, we know that many children with MIS-C were exposed or infected with SARS-CoV-2. Currently, the lack of a universal case definition of MIS-C has limited the number of cases that are accurately diagnosed and hampered with proper treatment of the disease. Further research into the clinical, epidemiological and immunological nature of MIS-C is desperately needed. MIS-C can be serious, even deadly, but most children who were diagnosed with this condition have gotten better with medical care."

Multisystem Inflammatory Syndrome in Children (MIS-C) associated with COVID-19

Clinical spectrum of COVID-19 and COVID-19-associated multisystem inflammatory syndromes in children. (n.d.). Retrieved August 18, 2020, from https://www.uptodate.com/contents/image?imageKey=PEDS%2F128295

Clinical spectrum of COVID-19 and COVID-19-associated multisystem inflammatory syndromes in children

- Journal of American Medical Association (JAMA)
- The New England Journal of Medicine

References for Multisystem Inflammatory Syndrome in Children (MIS-C) associated with COVID-19 by Journal/Source

Multisystem Inflammatory Syndrome in Children (MIS-C) associated with COVID-19 Organized by Country

Hoste, L., Van Paemel, R., & Haerynck, F. (2021). Multisystem inflammatory syndrome in children related to COVID-19: a systematic review. European journal of pediatrics, 180(7), 2019–2034. https://doi.org/10.1007/s00431-021-03993-5

Multisystem inflammatory syndrome in children related to COVID-19: a systematic review

This systematic review of 953 MIS-C cases compiles data regarding epidemiological risk factors of disease and common clinical manifestations. After analyzing the case studies, the authors argued for the WHO case definition of MIS-C as it best represented the longitudinal research. 


Systematic Review of 953 MIS-C Cases 

A majority of MIS-C patients were male and part of recognized socioeconomic minorities (Black, Hispanic/Latino). Co-morbidities are largely unknown among fatal cases and underlying health/genetic conditions, prior infections or immunizations have not been studied in MIS-C patients. Extensive research into patients’ backgrounds, including the deceased, must be reviewed and shared with clinicians. 

Comorbidies/Social Determinants of Health Present in MIS-C Patients

According to the Centers for Disease Control and Prevention, common symptoms of Multisystem Inflammatory Syndrome in Children (MIS-C) include:

- Fever
- Abdominal pain
- Vomiting
- Diarrhea
- Rash
- Bloodshot eyes
- Feeling extra tired
- Neurological symptoms in the central nervous system (CNS) and peripheral nervous system (PNS)

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