- ADAMTS13 levels, vWF antigen (the substrate of ADAMTS13) and natural anticoagulants (AT, PC, and PS) levels in the blood were measured in each of the 77 patients within seven days of admission to the hospital. 

Dependent Variables of the Investigation Between ADAMTS13 Levels and Covid-19 mortality

- 97.5% of patients had comorbidities 
- 73% of patients were older than 60 years. 


Comorbidity Details of Patients Involved in the Investigation Between ADAMTS13 Levels and COVID-19 mortality

- The median value of ADAMTS13 activity median value was 70 U/dL.
- The kaplan-meier analysis demonstrated that a significantly lower survival rate was seen in patients who had lower ADAMTS13 activity than the median value of 70 U/dL.  
- vWF antigen levels did not appear to be associated with risk of death from SARS-CoV-2 infection. 


Results of the Study Investigating the Relationship Between ADAMTS13 Levels and COVID-19 Mortality 

- It is important to note the high probability that the comorbidities in 97.5 % of patients could have contributed to the deaths of the patients.
- Small sample size of 77 patients 

Limitations of the Study Investigating the Relationship Between ADAMTS13 Levels and COVID-19 mortality

Kaplan-meier plot Results from Investigation of Relationship Between ADAMTS13 Levels and COVID-19 Mortality

- 77 patients with SARS_CoV-2 were investigated between march 1 and April 30, 2020 at the “Casa Sollievo della Sofferenza” Research Hospital. 

Santa Clara University

- SARS-CoV-2 infection can induce thrombotic microangiopathy (TMA), which is characterized as blood clot formation in the arteries and capillaries. ADAMTS13 plays a key role in the pathogenesis of TMA.

How ADAMTS13 levels relates to SARS-CoV-2 infection

Tiscia, G. L., Favuzzi, G., De Laurenzo, A., Cappucci, F., Fischetti, L., di Mauro, L., Miscio, G., Mirijello, A., Chinni, E., Grandone, E., & CSS COVID-19 Group (2020). Reduction of ADAMTS13 Levels Predicts Mortality in SARS-CoV-2 Patients. TH open : companion journal to thrombosis and haemostasis, 4(3), e203–e206. https://doi.org/10.1055/s-0040-1716379

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