A compensatory reduction in receptor availability at the synapses of a neuron with repeated exposure to an agonist.

Bowdoin College

A molecule that acts like a transmitter and binds to a receptor, causing a response similar to one caused by a transmitter. These molecules are usually drugs.

Agonist

Decreased responding to a drug after repeated exposures, generally as a consequence of up- or down- regulation of receptors. 

Functional tolerance

Breedlove, S. & Watson, N. (2017). Behavioral neuroscience, eighth edition. Oxford University Press.

Behavioral Neuroscience 8th Edition

A new medication is developed that effectively reduces anxiety. Researchers find that it achieves this effect by binding to the same neural receptor sites as a naturally occurring calming neurotransmitter and producing a similar calming effect. How is this medication functioning at the receptor site?

A compensatory increase in receptor availability at the synapse of a neuron with repeated exposure to an antagonist.

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