- Break-bone Fever
- Dengue Hemorrhagic Fever

Tulane University

Georgetown University

- Pathogenesis/Vector
- Presentation of Maternal Infection
- Diagnosis
- Fetal/Neonatal Abnormalities
- Vaccines

Dengue

Dengue viruses are vector-borne diseases commonly found in tropical and subtropical climates that cause fever, nausea, rashes and body aches. In high risk areas, Dengue is the leading cause of death therefore it is essential that there is appropriate investment in surveillance methods that can prevent outbreaks of Dengue. 

Nausheen, F., S. Bashir, S., &amp; N. Atapattu, D. (2018). Pregnancy associated arbovirus infections. Clinical Microbiology and Infectious Diseases, 3(2). https://doi.org/10.15761/cmid.1000138 

Pregnancy Associated Arbovirus Infections

Dengue Fever is diagnosed through an analysis of antibodies using ELISA or other molecular assays. Specifically, physicians look for viral antigens or RNA within the tissue that are associated with the arbovirus. 

Diagnosing Dengue Fever

Dengue is transmitted by the Aedes species of mosquitoes. Infections are characterized as vasculopathy as a result of complement activation and enhancing antibodies. 

Dengue Pathogenesis/Vector

These include fetal/neonatal hemorrhages. 

Fetal/Neonatal Anomalies from Dengue

Available vaccines for the various serotypes of Dengue are under review and may become commercially available. 

Vaccines for Dengue

Dengue is now prevalent in Yucatan and other coastal, tropical areas. All four dengue serotypes are present and incidence rates peaked in 2002, 2007 and 2009.

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