University of South Florida

The classic definition: A compound that has clinical antipsychotic efficacy while producing minimal catalepsy. 
Now: An atypical agent is now seen as an agent that 

1. decreased propensity to produce catalepsy or other movement disorders, 

2. does not elevate prolactin concentrations, 

3. significantly reduced positive and negative symptoms of schizophrenia.

Atypical Antipsychotics - What is an atypical Antipsychotic?

Markowitz, J. S., Brown, C. S., &amp; Moore, T. R. (1999). Atypical antipsychotics part I: Pharmacology, pharmacokinetics, and efficacy. Annals of Pharmacotherapy, 33(1), 73–85. https://doi.org/10.1345/aph.17215 

Atypical Antipsychotics; Part 1: Pharmacology, Pharmacokinetics, and Efficacy

Table 2

Clozapine the conventional antipsychotic loxapine was the first atypical drug to become available widely in the US.

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