Tricyclic Antidepressants
Tricyclic (or heterocyclic) antidepressants inhibit the reuptake of serotonin and/or norepinephrine, and are thus called due to their three (or more)-ring chemical structure. Some examples include:
- Amitriptyline (Elavil)
- Nortriptyline (Aventyl)
- Maprotiline hydrochloride (Ludiomil)
- Desipramine hydrochloride (Norpramin)
- Clomipramine (Anafranil)
A similar drug is Bupropion (Wellbutrin), which is an aminoketone that weakly blocks norepinephrine, serotonin, and dopamine reuptake.
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Side Effects of Antidepressants
A clinician is considering two different types of medication for a patient. Medication A primarily works by increasing the amount of serotonin available between nerve cells. Medication B works by increasing the availability of both serotonin and norepinephrine. Which of the following statements accurately distinguishes between the mechanisms of these two medications?
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